New clues into how gut microbes help regulate cholesterol and fat metabolism

Mónica Quinzo - Recent research has identified a microbial process that helps maintain metabolic balance and prevent fat accumulation. Understanding this interaction may provide insights into metabolic health and disease prevention.Bile acids and gut microbiota’s role in digestion of dietary fatsBile acids are produced in the liver from cholesterol and released into the small intestine to help digest dietary fats after a meal.Most bile acids are reabsorbed and recycled, while some are transformed by gut bacteria into secondary bile acids. Certain bacteria, such as Lactobacilli and Clostridioides species, can modify bile acids in several ways.These modified bile acids influence metabolic processes by regulating cholesterol levels, fat digestion, and glucose metabolism. For instance, some modified bile acids, such as the deoxycholic acid (DCA), activate a liver receptor that reduces bile acid production, being a key regulator in metabolic health. The role of gut microbiota in fat storageRecent mice research has uncovered a novel host-microbiota partnership that helps regulate bile acid production and fat metabolism. Scientists identified a compound called bile acids-methylcysteamine (BA-MYC), produced by the host intestine.When BA-MYC is present, it reduces the activity of the mentioned liver receptor, leading to increased bile acid production. This process depends on gut bacteria, as they provide the necessary bile acid precursors for BA-MYC formation.The findings suggest the existence of a strong host and gut microbiota comunication that contributes to metabolic balance by adjusting bile acid production in response to dietary intake and nutritional status. Potential health implicationsThe study also showed that supplementing mice on a high-cholesterol diet with BA-MYC-related compounds reduced fat buildup in the liver. These results suggest that modifying gut microbiota or targeting bile acid metabolism could be a potential strategy for managing metabolic disorders such as type II diabetes, obesity, and high cholesterol.Researchers also detected similar BA-MYC molecules in human blood, indicating that this process may occur in humans as well. If confirmed, these findings could open new possibilities for preventive and therapeutic approaches in metabolic health. How to support gut microbiota for metabolic healthMaintaining a balanced gut microbiota may help regulate bile acid metabolism and cholesterol levels. Diet plays a central role in supporting beneficial gut bacteria. A fiber-rich diet that includes whole grains, vegetables, and legumes promotes microbial diversity.Probiotic foods such as yogurt, kefir, and fermented vegetables can also help maintain a healthy gut environment. In addition, recent studies highlight the potential of probiotics, such as Lactobacillus and Bifidobacterium, in supporting cholesterol metabolism by modulating bile acids and reducing cholesterol absorption. While evidence suggests possible benefits for cardiovascular health, more research is needed before making broad recommendations.Healthy fats, including those found in olive oil, nuts, and fatty fish, may contribute to metabolic stability. Regular physical activity has also been linked to improved gut microbiota composition. Conversely, processed foods high in sugar and refined carbohydrates can disrupt gut bacteria and negatively impact metabolic health. ConclusionGut microbiota contributes to cholesterol metabolism and fat regulation by influencing bile acid production. Research suggests that microbial processes help prevent excessive fat accumulation, with potential implications for metabolic health. While further studies are needed, dietary and lifestyle choices that support gut health may play a role in maintaining metabolic balance. - Source: https://www.gutmicrobiotaforhealth.comDid you know?BrainGrowing evidence from the microbiome field shows that harnessing gut microbes through diet can beneficially impact brain and behaviour.

New clues into how gut microbes help regulate cholesterol and fat metabolism

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Namibian Sun 2025-08-18

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New clues into how gut microbes help regulate cholesterol and fat metabolism

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Namibian Sun 2025-08-18

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